The first DMAC/”PAC003” method used a proprietary standard with limited availability. It was used to measure PACs in the petitions leading to the urinary tract health claims validated in France.

Between 2004 and 2007, the French AFSSA (Food Security Agency) validated various health claims stating that “the daily intake of 36 mg cranberry PACs contributes to preventing the adhesion of uropathogenic P-fimbriated E.coli to bladder cells”.  If the adhesion is prevented, the bacteria will not grow or lead to infection and will be simply flushed out of the body in the urine stream.

This claim was first validated for cranberry juice concentrate and concentrated juice powder, further also for cranberry juice cocktail, fresh and frozen cranberries and puree.

In 2010, the same Agency validated the use of the DMAC/A2/microplate assay as the most specific method for cranberry PACs quantitation.

fondateurs DMACLaboratoires de validation